In 1963, the U.S. government launched a covert space mission sending hundreds of men, women and children on a century-long voyage aboard the starship Ascension to populate a new world. Nearly 50 years into the journey, as they approach the point of no return, a mysterious murder of a young woman causes the ship’s population to question the true nature of their mission.

Sanctuary follows the adventures of the beautiful, enigmatic and always surprising Dr. Helen Magnus, a brilliant scientist who holds the secrets of a clandestine population called Abnormals - a group of strange and sometimes terrifying beings that hide among humans. Magnus seeks to protect this threatened phenomena as well as unlock the mysteries behind their existence.