Bionic Woman is a re-imagining of the original television series, The Bionic Woman. The series revolves around bartender Jaime Sommers, who is saved from death after receiving experimental medical implants. While adjusting to her new bionic powers and raising a rebellious younger sister, Jaime agrees to work for the Berkut Group, a quasi-governmental private organization that performed her surgery.

In a distant part of the universe, a civilization of humans live on planets known as the Twelve Colonies. In the past, the Colonies have been at war with a cybernetic race known as the Cylons. 40 years after the first war the Cylons launch a devastating attack on the Colonies. The only military ship that survived the attack takes up the task of leading a small fugitive fleet of survivors into space in search of a fabled refuge known as Earth.