Stitchers follows Kirsten, a young woman recruited into a covert government agency to be 'stitched' into the minds of the recently deceased, using their memories to investigate murders and decipher mysteries that otherwise would have gone to the grave. Working alongside Kirsten is Cameron, a brilliant neuroscientist whose passion for the program is evident in his work. The secret program is headed by Maggie, a skilled veteran of covert operations, and includes Linus, a socially immature bioelectrical engineer and communications technician. Kirsten's roommate, Camille, a gifted computer science grad student, is also recruited to use her skills to assist Kirsten in her new role as a 'stitcher.'

After saving the life of an international diplomat in Washington D.C., a pair of U.S. Secret Service agents are whisked away to a covert location in South Dakota that houses supernatural objects that the U.S. Government has collected over the centuries. Their new assignment: retrieve some of the missing objects and investigate reports of new ones.