Set in the future, Logan and Professor Charles Xavier must cope with the loss of the X-Men when a corporation led by Nathaniel Essex is destroying the world leaving it to destruction, with Logan's healing abilities slowly fading away and Xavier's Alzheimer's forcing him to forget. Logan must defeat Nathaniel Essex with the help of a young girl named Laura Kinney, a female clone of Wolverine.

"Days of Future Past" is a popular storyline in the Marvel Comics comic book The Uncanny X-Men issues #141 and #142, published in 1981. It deals with a dystopian alternative future in which mutants are incarcerated in internment camps. An older Kitty Pryde transfers her mind into the younger, present-day Kitty Pryde, who brings the X-Men to prevent a fatal moment in history which triggers anti-mutant hysteria.

When a cure is found to treat mutations, lines are drawn amongst the X-Men, led by Professor Charles Xavier, and the Brotherhood, a band of powerful mutants organized under Xavier's former ally, Magneto.

Professor Charles Xavier and his team of genetically gifted superheroes face a rising tide of anti-mutant sentiment led by Col. William Stryker in this sequel to the Marvel Comics-based blockbuster X-Men. Storm, Wolverine and Jean Grey must join their usual nemeses Magneto and Mystique to unhinge Stryker's scheme to exterminate all mutants.

En route to the honeymoon of William Riker to Deanna Troi on her home planet of Betazed, Captain Jean-Luc Picard and the crew of the U.S.S. Enterprise receives word from Starfleet that a coup has resulted in the installation of a new Romulan political leader, Shinzon, who claims to seek peace with the human-backed United Federation of Planets. Once in enemy territory, the captain and his crew make a startling discovery: Shinzon is human, a slave from the Romulan sister planet of Remus, and has a secret, shocking relationship to Picard himself.

Two mutants, Rogue and Wolverine, come to a private academy for their kind whose resident superhero team, the X-Men, must oppose a terrorist organization with similar powers.

When an alien race and factions within Starfleet attempt to take over a planet that has "regenerative" properties, it falls upon Captain Picard and the crew of the Enterprise to defend the planet's people as well as the very ideals upon which the Federation itself was founded.

While on routine patrol, Captain Jean-Luc Picard gets word from Starfleet Headquarters that the Borg, an insidious race of half-machine, half-organic aliens, have entered Federation Space and are on a direct course for Earth. Violating direct orders to remain uninvolved, Picard leads the newly commissioned USS Enterprise E into Starfleet's massive assault against their deadliest foe. Captain Picard and his crew pursue the Borg back in time to stop them from preventing Zefram Cochrane from initiating first contact with alien life.

Captain Jean-Luc Picard and the crew of the Enterprise-D find themselves at odds with the renegade scientist Soren who is destroying entire star systems. Only one man can help Picard stop Soren's scheme...and he's been dead for seventy-eight years.

In the year 10,191, the world is at war for control of the desert planet Dune -- the only place where the time-travel substance Spice can be found. But when one leader gives up control, it's only so he can stage a coup with some unsavory characters.